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Sixteen-year-old Rose Nolan arrives on Ellis Island in 1911 in the hopes of starting a new life, but after most of her family is sent back to Ireland, she must find her own way in a new country and fend for herself and her younger sister.

Rebekah, a fifteen-year-old Jewish immigrant arriving in New York City in 1902, almost abandons her dream of getting an education when she is forced to work in a sweatshop.

While conducting research for a school paper on smallpox, Mitty finds an envelope containing 100-year-old smallpox scabs and fears that he has infected himself and all of New York City.

When sixteen-year-old Emerson Watts learns the truth about Nikki, the teen supermodel into whose body Emerson's brain was transplanted, she finds that there is only one person to turn to for help--especially since her loved ones seem to be furious with her.

Adam, who is dyslexic and has great difficulty with his homework, struggles to find the right school, resist the lure of drugs, and endure the jealousy of his older sister Caroline.

A seventeen-year-old boy, former member of a tough New York gang, a blind and talented twelve-year-old musician, the Austin family, and Canon Tallis are among the key characters who become involved in a frightening and evil scheme relying on the ability of a refined laser to give complete power over people's minds.

When she and her mother move to an apartment in New York City after her parents decide on a trial separation, sixteen-year-old Sammie learns to deal with her mother's fragile mental state, her best friend's self-centeredness, several new friendships, and her own budding sexuality.

Fifteen-year-old Camilla gains new maturity through her relationship with her best friend's brother and the growing realization that her parents are fallible individuals.